LY2606368
货号：
21490-25mg 基本售价：
12460.0 元 规格：
25 mg
产品信息
概述| 货号 | 21490-25mg |
| 描述 | LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of <13 nM in a viability study of multiple colorectal cancer cell lines.1,2 Inhibition of Chk1 causes double-strand DNA breakage in cells leading to an excessive cell damage burden and subsequent cell death.1,2In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM.1 LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.3 |
| 别名 | Prexasertib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.King, C.,Diaz, H.B.,McNeely, S., et al. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Mol. Cancer Ther. 14(9), 2004-2013 (2015).
2.Yin, Y.,Shen, Q.,Zhang, P., et al. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am. J. Cancer Res. 7(3), 473-483 (2017).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 365.4 |
| 分子式 | C18H19N7O2 |
| CAS号 | 1234015-52-1 |
| 稳定性 | ≥ 2 years |
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