(R)-IMPP
货号：
20861-25mg 基本售价：
12390.0 元 规格：
25 mg
产品信息
概述| 货号 | 20861-25mg |
| 描述 | (R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 µM).1 It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels.1 (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Petersen, D.N.,Hawkins, J.,Ruangsiriluk, W., et al. A small-molecule anti-secretagogue of PCSK9 targets the 80S ribosome to inhibit PCSK9 protein translation. Cell. Chem. Biol. 23, 1-10 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 389.5 |
| 分子式 | C24H27N3O2 |
| 稳定性 | ≥ 2 years |
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