| 货号 | 1592/50 |
| 别名 | N3-Cyclopropyl-7-[[4-(1-methylethyl |
| 供应商 | Tocris |
| 生物活性 | Potent, selective non-peptide PAR1 receptor antagonist (IC50 = 70 nM). Inhibits haTRAP-induced- but not γ-thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR1 agonist- or thrombin-induced increases in cytosolic Ca2+ in vascular smooth muscle cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 444.41 |
| 分子式 | C23H25N5.2HCl |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 245520-69-8 |
| 参考文献 | Lidingtonet al (2005) A role for proteinase-activated receptor 2 and PKC-ε in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. Am.J.Physiol.Cell Physiol. 289 C1437. PMID: 16079188. Ahnet al (2000) Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem.Pharmacol. 60 1425. PMID: 11020444. Ahnet al (1999) Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg.Med.Chem.Lett. 9 2073. PMID: 10450984. |