| 货号 | 3263/50 |
| 别名 | 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1- |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 335.4 |
| 分子式 | C20H21N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl |
| 参考文献 | Nomaet al (2008) The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 134 1981. PMID: 18439605. Huet al (2005) Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells. Am.J.Physiol.Renal Physiol. 289 F816. PMID: 16159901. Byfieldet al (2004) SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 65 744. PMID: 14978253. |