| 货号 | 3912/50 |
| 别名 | 4-(7,8,9,10-Tetrahydro-5,7,7,10.10- |
| 供应商 | Tocris |
| 生物活性 | Potent RXR antagonist (IC50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 483.56 |
| 分子式 | C29H29N3O4 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Nieet al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18 624. PMID: 28099842. Suzukiet al (2009) Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells. Biol.Pharm.Bull. 32 1177. PMID: 19571381. Aliqueet al (2006) Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration. Br.J.Pharmacol. 149 65. PMID: 16847438. Ebisawaet al (1999) Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem.Pharm.Bull. 47 1778. PMID: 10748721. |