| 货号 | 89450-50mg |
| 描述 | Cholesteryl ester transfer protein (CETP) is an exchange protein which transfers cholesteryl esters from HDL to VLDL, IDL, and LDL in exchange for triglycerides.1,2 Dalcetrapib is an inhibitor of CETP that exhibits an IC50 value of 9 µM for plasma CETP in rabbits.3 Inhibition of CETP by dalcetrapib in rabbits given an atherogenic diet leads to elevation of HDL, decreased VLDL, and attenuation of the induced atherosclerosis.3 In human subjects, dalcetrapib also inhibits CETP activity and increases plasma HDL levels but it does not reduce the risk of recurrent cardiovascular events.2,4 |
| 别名 | JTT-705; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Le Goff, W.,Guerin, M. and Chapman, M.J. Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyslipidemia. Pharmacology & Therapeutics 101, 17-38 (2004). 2.Rader, D.J. Molecular regulation of HDL metabolism and function: implications for novel therapies. Journal of Clinical Investigation 116(12), 3090-3100 (2006). 3.Okamoto, H.,Yonemori, F.,Wakitani, K., et al. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature 406, 203-206 (2000). 4.Schwartz, G.G.,Olsson, A.G.,Abt, M., et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. New England Journal of Medicine 367(22), 2089-2099 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 389.6 |
| 分子式 | C23H35NO2S |
| CAS号 | 211513-37-0 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |