| 货号 | 19437-2.5mg |
| 描述 | Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells.1,2 It suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of matrix metalloproteinase-9.3 At 2 µM, ascochlorin profoundly increases the expression of p53 by increasing protein stability in cancer cells, and, at 50 µm, it inhibits signaling through STAT3.4,5 Ascochlorin also binds and inhibits the mitochondrial cytochrome bc1 complex, blocking reduction of cytochrome b by ubiquinone.6 |
| 别名 | Antibiotic LL-Z1272γ;Ilicicolin D;NSC 287492; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tamura, G.,Suzuki, S.,Takatsuki, A., et al. Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I). J.Antibiot.(Tokyo) 21(9), 539-544 (1968). 2.Takatsuki, A.,Tamura, G. and Arima, K. Antiviral and antitumor antibiotics. XIV. Effects of ascochlorin and other respiration inhibitors on multiplication of Newcastle disease virus in cultured cells. App.Microbiol. 17(6), 825-829 (1969). 3.Hong, S.,Park, K.K.,Magae, J., et al. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: Inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. The Journal of Biological Chemisty 280(26), 25202-20209 (2005). 4.Jeong, J.H.,Nakajima, H.,Magae, J., et al. Ascochlorin activates p53 in a manner distinct from DNA damaging agents. International Journal of Cancer 124(12), 2797-2803 (2009). 5.Dai, X.,Ahn, K.S.,Kim, C., et al. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Mol.Oncol. 9(4), 818-833 (2015). 6.Berry, E.A.,Huang, L.s.,Lee, D.W., et al. Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex. Biochim.Biophys.Acta. 1797(3), 360-370 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 404.9 |
| 分子式 | C23H29CIO4 |
| CAS号 | 26166-39-2 |
| 稳定性 | ≥ 2 years |
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