| 货号 | 2727/50 |
| 别名 | [1-(Quinolin-5-yl)-5-cyclopropyl-1H |
| 供应商 | Tocris |
| 生物活性 | Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+uptakein vitro(IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo(EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 393.27 |
| 分子式 | C17H16N6O.2HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| CAS号 | 241800-97-5 |
| 参考文献 | Clements-Jeweryet al (2004) Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 142 57. PMID: 15037516. Maralaet al (2002) Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1. Eur.J.Pharmacol. 451 37. PMID: 12223226. Knightet al (2001) A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 297 254. PMID: 11259552. |