| 货号 | 1321/50 |
| 别名 | 3-(Dimethylamino)-N-[3-[(4-hydroxyb |
| 供应商 | Tocris |
| 生物活性 | Potent, selective inhibitor of c-Raf in vitro(IC50 = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2 μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μM). Also available as part of the MAPK Cascade Inhibitor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 389.45 |
| 分子式 | C23H23N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 208260-29-1 |
| 参考文献 | Wartenberget al (2001) Down-regulation of intrinsic p-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J.Biol.Chem. 276 17420. PMID: 11279018. Hall-Jacksonet al (1999) Paradoxical activation of Raf by a novel Raf inhibitor. Chem.Biol. 6 559. PMID: 10421767. |