| 货号 | 3570/50 |
| 别名 | (Z)-Pregna-4,17(20)-diene-3,16-dion |
| 供应商 | Tocris |
| 生物活性 | Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 312.45 |
| 分子式 | C21H28O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming |
| CAS号 | 39025-23-5 |
| 参考文献 | Xiao and Singh (2008) z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitroandin vivo. Mol.Cancer Ther. 7 171. PMID: 18202020. Singhet al (2007) Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate-dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 67 7439. PMID: 17671214. Meyeret al (2005) Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. J.Med.Chem. 486955. |