ZCL 278 (50 MG)
货号：
4794/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 4794/50 |
| 别名 | 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide |
性能| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >95 % |
| 计算分子量 | 584.89 |
| 分子式 | C21H19BrClN5O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Frieslandet al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261. PMID: 23284167. |
