| 货号 | 2077/50 |
| 别名 | N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hy |
| 供应商 | Tocris |
| 生物活性 | Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 366.41 |
| 分子式 | C21H22N2O4 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO |
| CAS号 | 127408-30-4 |
| 参考文献 | Fukunariet al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197. PMID: 9128839. Nakajimaet al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381. |