| 货号 | 5422/50 |
| 别名 | N-[4-[(6,7-Dimethoxy-4-quinolinyl)o |
| 供应商 | Tocris |
| 生物活性 | Potent VEGFR inhibitor (IC50 = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 501.51 |
| 分子式 | C28H24FN3O5< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Youet al (2012) VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res. 71 4758. PMID: 21613405. Yakeset al (2011) Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol.Cancer Ther. 10 2298. PMID: 21926191. |