| 货号 | 4434/50 |
| 别名 | 3,6-Dibromo-α-[(dimethylamino)methyl |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 426.15 |
| 分子式 | C17H18Br2N2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Wegneret al (2008) N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J.Biol.Chem. 283 15912. PMID: 18430734. Guerriero and Weiszet al (2006) N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am.J.Physiol.Cell Physiol. 292 C1562. PMID: 17092993. Petersonet al (2004) Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol. 11 747. PMID: 15235593. |