| 货号 | 3803/50 |
| 别名 | 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3, |
| 供应商 | Tocris |
| 生物活性 | Novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β(IC50>200μM for Hsp90β). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 556.4 |
| 分子式 | C25H23Cl2N7O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 1134156-31-2 |
| 参考文献 | Maciaset al (2011) Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J.Med.Chem. 54 4034. PMID: 21526763. Masseyet al (2010) ATPases as drug targets: insights from heat shock proteins 70 and 90. J.Med.Chem. 53 7280. PMID: 20608738. Masseyet al (2009) A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother.Pharmacol. 66 535. PMID: 20012863. Williamsonet al (2009) Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. J.Med.Chem. 52 1510. PMID: 19256508. |