| 货号 | 3829/50 |
| 别名 | 4-[(Diphenylmethoxy)methyl]-1-[3-(4 |
| 供应商 | Tocris |
| 生物活性 | Blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 466.05 |
| 分子式 | C29H35NO2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 30 mM in ethanol |
| CAS号 | 136647-02-4 |
| 参考文献 | Chandyet al (2004) K+ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 25 280. PMID: 15120495. Chandyet al (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39 1269. PMID: 11384714. Hansonet al (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 126 1707. PMID: 10372812. |