| 货号 | 1144/25 |
| 别名 | 1,4-Diamino-2,3-dicyano-1,4-bis[2-a |
| 供应商 | Tocris |
| 生物活性 | Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Negative control U0124 (Cat. No. 1868) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 380.48 |
| 分子式 | C18H16N6S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 109511-58-2 |
| 参考文献 | Kineharaet al (2013) Protein kinase C regulates human pluripotent stem cell self-renewal. PLoS One 8 e54122. PMID: 23349801. Namuraet al (2001) Intravenous administraton of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc.Natl.Acad.Sci.U.S.A. 98 11569. PMID: 11504919. Davieset al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351. Dunciaet al (1998) MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg.Med.Chem.Lett. 8 2839. PMID: 9873633. Favataet al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 273 18623. PMID: 9660836. |