| 货号 | 3863/50 |
| 别名 | 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1 |
| 供应商 | Tocris |
| 生物活性 | Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 512.46 |
| 分子式 | C20H15F3N4O3.CH3SO3H |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 147059-75-4 |
| 参考文献 | Poonet al (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507 329. PMID: 24646995. Gootzet al (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 40 2691. PMID: 9124824. Neu and Chin (1994) In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 38 2615. PMID: 7872757. |