| 货号 | 3599/50 |
| 别名 | 1-[4-[4-[[2-[(1E)-2-[4-(trifluorome |
| 供应商 | Tocris |
| 生物活性 | Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 468.47 |
| 分子式 | C25H23F3N4O2 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 366017-09-6 |
| 参考文献 | Spectoret al (2007) Small molecule HER-2 tyrosine kinase inhibitors. Breast Cancer Res. 9205. Nagasawaet al (2006) Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitroandin vivo. Int.J.Urol. 13585. Sridharet al (2003) Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 4 397. PMID: 12850190. |