SZL P1-41 (50 MG)
货号：
5076/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 5076/50 |
| 别名 | 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one |
性能| 供应商 | Tocris |
| 生物活性 | Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivoandin vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 420.52 |
| 分子式 | C24H24N2O3 |
| 可溶性/溶解性 | Soluble to 20 mM in 1eq. HCl and to 5 mM in DMSO with gentle warming |
| 参考文献 | Chanet al (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154 556. PMID: 23911321. |
