| 货号 | 4044/50 |
| 别名 | 2-(4-Methyl-1-piperazinyl)-5-(2,3,5 |
| 供应商 | Tocris |
| 生物活性 | Blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+ channels. Analog of lamotrigine (Cat. No. 1611). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 372.68 |
| 分子式 | C15H16Cl3N5< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Stefaniet al (1998) On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 125 1058. PMID: 9846645. Grahamet al (1994) Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 269 854. PMID: 7910213. Leachet al (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24 1063. PMID: 8100654. |