| 货号 | 5342/50 |
| 别名 | 2,3-Dihydro-6,7-diphenyl-2-thioxo-4 |
| 供应商 | Tocris |
| 生物活性 | Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 332.38 |
| 分子式 | C18H12N4OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Grecoet al (2016) Synthesis and structure determination of SCR7, a DNA ligase inhibitor Teterahedron Lett. 573204. Grecoet al (2016) SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. DNA Repair (Amst) 43 18. PMID: 27235626. Chuet al (2015) Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat.Biotechnol. 33 543. PMID: 25803306. Maruyamaet al (2015) Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat.Biotechnol. 33 538. PMID: 25798939. |