| 货号 | 2299/50 |
| 别名 | (6aS-trans)-11-Chloro-6,6a,7,8,9,13 |
| 供应商 | Tocris |
| 生物活性 | High affinity dopamine D1/D5 receptor antagonist; displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 394.73 |
| 分子式 | C19H20ClNO.HBr |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Wuet al (2005) Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. J.Med.Chem. 48 680. PMID: 15689153. Terry and Katz (1994) A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393. Psychopharmacology 113 328. PMID: 7862841. McQuadeet al (1991) In vivo binding of SCH 39166: a D-1 selective antagonist. J.Pharmacol.Exp.Ther. 257 42. PMID: 1826927. |