| 货号 | 3188/50 |
| 别名 | N-[2-(Dimethylamino)ethyl]-N-[[4'-[[ |
| 供应商 | Tocris |
| 生物活性 | Selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 584.66 |
| 分子式 | C34H45N3O.2HCl |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 791789-61-2 |
| 参考文献 | Thomaset al (2006) SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology 51 566. PMID: 16846620. Thomas (2006) 5-ht5A receptors as a therapeutic target. Pharmacol.Ther. 111 707. PMID: 16516972. Corbettet al (2005) Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 154014. |