| 货号 | 3211/50 |
| 别名 | 6-[2-(1,1-Dimethylethyl)-5-(6-methy |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 343.42 |
| 分子式 | C21H21N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl |
| CAS号 | 356559-20-1 |
| 参考文献 | Higashiyamaet al (2007) Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis Exp.Mol.Pathol. 83 39. PMID: 17274978. Lapinget al (2007) Tumor-specific efficacy of transforming growth factor-βRI inhibition in eker rats. Clin.Cancer Res. 13 3087. PMID: 17505012. Grygielkoet al (2005) Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis. J.Pharmacol.Exp.Ther. 313 943. PMID: 15769863. |