| 货号 | 1960/50 |
| 别名 | N-(2-Methyl-6-benzoxazolyl)-N'-1,5-n |
| 供应商 | Tocris |
| 生物活性 | Selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 319.32 |
| 分子式 | C17H13N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming |
| CAS号 | 249889-64-3 |
| 参考文献 | Duxonet al (2001) Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology 153 203. PMID: 11205420. Porteret al (2001) 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. Bioorg.Med.Chem.Lett. 11 1907. PMID: 11459658. Smartet al (2001) SB-334867-A: the first selective orexin-1 receptor antagonist. Br.J.Pharmacol. 132 1179. PMID: 11250867. Hayneset al (2000) A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul.Pept. 96 45. PMID: 11102651. |