| 货号 | 1612/50 |
| 别名 | (2R)-1-[(3-Hydroxyphenyl)sulfonyl]- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT7 receptor antagonist (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B and < 6.0 for 5-HT1A, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4 and 5-HT6 receptors respectively). Brain penetrant in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 388.95 |
| 分子式 | C18H28N2O3S.HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in DMSO |
| CAS号 | 201038-74-6 |
| 参考文献 | Koganet al (2002) DR4004, a putative 5-HT7 receptor antagonist, also has functional activity at the dopamine receptor. Eur.J.Pharmacol. 449 105. PMID: 12163113. Haganet al (2000) Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist. Br.J.Pharmacol. 130 539. PMID: 10821781. Lovellet al (2000) A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) J.Med.Chem. 43 342. PMID: 10669560. |