| 货号 | 1376/50 |
| 别名 | (R)-[[2-Phenyl-4-quinolinyl)carbony |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3). Displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Active in vivo, inhibiting agonist-induced pupillary constriction. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 396.44 |
| 分子式 | C25H20N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 174635-53-1 |
| 参考文献 | Giardinaet al (1997) Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. J.Med.Chem. 40 1794. PMID: 9191956. Medhurstet al(1997)In vitroandin vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br.J.Pharmacol. 122 469. PMID: 9351503. |