| 货号 | 1371/50 |
| 别名 | N-(1-Methyl-1H-indol-5-yl)-N'-3-pyri |
| 供应商 | Tocris |
| 生物活性 | 5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B,2Cand2A respectively. Orally active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 302.76 |
| 分子式 | C15H14N4O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 143797-63-1 |
| 参考文献 | Kennettet al (1995) Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 118 178. PMID: 7617805. Kennettet al(1994)In vivo properties of SB 200646A, a 5-HT2C/2B recepor antagonist. Br.J.Pharmacol. 111 797. PMID: 7912626. Forbeset al(1993)N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist. J.Med.Chem. 36 1104. PMID: 8478907. |