| 货号 | 4508/50 |
| 别名 | 1,2-Dihydro-N-[4-methoxy-3-(4-methy |
| 供应商 | Tocris |
| 生物活性 | Inverse agonist of 5-HT2C receptors (pKi = 8.18 at human 5-HT2C INI receptors). Also an antagonist of human α2-adrenoceptors. Displays negligible affinity for α1A-adrenoceptors, histamine H1 receptors and muscarinic M1receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 452.98 |
| 分子式 | C25H28N4O2 |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 25 mM in DMSO |
| 参考文献 | Dekeyneet al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization. J.Pharmacol.Exp.Ther. 340 765. PMID: 22178753. Millanet al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization. J.Pharmacol.Exp.Ther. 340 750. PMID: 22178752. |