| 货号 | 3432/50 |
| 别名 | 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4 |
| 供应商 | Tocris |
| 生物活性 | Potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 528.5 |
| 分子式 | C22H23F3N4O6S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 263-849-50-9 |
| 参考文献 | Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28664. Beauvergeret al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489. PMID: 15601626. Della-Zuanaet al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28628. |