| 货号 | 1672/50 |
| 别名 | (7α,17α)-17-Hydroxy-3-oxo-7-propylpre |
| 供应商 | Tocris |
| 生物活性 | Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 440.66 |
| 分子式 | C25H37O4K |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 76676-34-1 |
| 参考文献 | Rahmouniet al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199. PMID: 10607876. Kimet al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213. PMID: 9879980. Perroteauet al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853. PMID: 6323881. |