| 货号 | 1635/50 |
| 别名 | (3aR,7aR)-Octahydro-2-[1-imino-2-(2 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective tachykinin NK1 receptor antagonist (Ki values are 2.9 nM and > 10 μM for rat NK1, and rat NK2 and NK3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo, possibly partly via inhibition of calcium channels. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 438.57 |
| 分子式 | C29H30N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 135911-02-3 |
| 参考文献 | Beaujouanet al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793. PMID: 7682138. Rupniaket al (1993) Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580. Br.J.Pharmacol. 110 1607. PMID: 8306108. Fonget al (1992) Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. J.Biol.Chem. 267 25668. PMID: 1281470. Garretet al (1991) Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc.Natl.Acad.Sci.U.S.A. 88 10208. PMID: 1719549. |