| 货号 | 4391/50 |
| 别名 | 2-[[4-Amino-5-[5-iodo-4-methoxy-2-( |
| 供应商 | Tocris |
| 生物活性 | Potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are >10μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 474.29 |
| 分子式 | C17H23IN4O4< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Syed and Kennedy (2012) Pharmacology of P2X receptors WIREs.Membr.Transp.Signal. 116. Jahangiret al (2009) Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain. Bioorg.Med.Chem.Lett. 19 1632. PMID: 19231178. |