| 货号 | 4181/50 |
| 别名 | 5-(6-Quinolinylmethylene)-2-[(2-thi |
| 供应商 | Tocris |
| 生物活性 | ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 351.45 |
| 分子式 | C18H13N3OS2< |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Yuet al (2012) CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage. Cancer Res. 72 5448. PMID: 22962268. Kojimaet al (2009) The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 100 1128. PMID: 19385969. Vassilevet al (2006) Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc.Natl.Acad.Sci. 10310660. |