Reversan (50 MG)
货号：
3722/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 3722/50 |
| 别名 | N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 441.52 |
| 分子式 | C26H27N5O2 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 313397-13-6 |
| 参考文献 | Burkhartet al (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69 6573. PMID: 19654298. |
