| 货号 | 4281/50 |
| 别名 | 3-[(3-Chlorophenoxy)methyl]-1-(tetr |
| 供应商 | Tocris |
| 生物活性 | Selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ(IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 396.27 |
| 分子式 | C17H18ClN5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Etchegarayet al (2010) Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 5 e10303. PMID: 20421981. Menget al (2010) Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc.Natl.Acad.Sci.USA 107 15240. PMID: 20696890. Waltonet al (2009) Selective inhibition of casein kinase 1ε minimally alters circadian clock period. J.Pharmacol.Exp.Ther. 330 430. PMID: 19458106. |