PA 1 dihydrochloride (50 MG)
货号：
5463/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 5463/50 |
| 别名 | 3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamide dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Photoswitchable epithelial sodium channel (ENaC) blocker (IC50 values are 90 and 390 nM for αβγandδβγENaCs, respectively, in the trans conformation). Switches conformation from cistotrans at 500 nm and transtocis at 400 nm. Blocks ENaCs with greater efficacy in the cis conformation, in comparison to the trans conformation, in Xenopus oocytes and HEK293t cells. Partially blocks δβγENaCs in the trans conformation and exhibits near maximal block of δβγENaCs in the cis conformation. Amiloride derivative. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 482.75 |
| 分子式 | C18H16ClN9O.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Schönbergeret al (2014) Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat.Chem. 6 712. PMID: 25054942. |
