| 货号 | 4782/50 |
| 别名 | N-[[1-(Dimethylamino)cyclopentyl]me |
| 供应商 | Tocris |
| 生物活性 | Potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 448.98 |
| 分子式 | C24H32lN2O4< |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in DMSO |
| 参考文献 | Moritaet al (2008) Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 326 633. PMID: 18448867. Caulfieldet al (2001) The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 44 2679. PMID: 11495577. |