| 货号 | 2738/50 |
| 别名 | (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-mo |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 438.04 |
| 分子式 | C25H40ClNO3 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO |
| CAS号 | 187652-71-7 |
| 参考文献 | Weiret al (2004) The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. Br.J.Anaesth. 92 704. PMID: 15033889. Visseret al (2002) Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo. J.Pharmacol.Exp.Ther. 303 616. PMID: 12388643. Hill-Venninget al (1996) The anaesthetic action and modulaton of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 35 1209. PMID: 9014136. |