| 货号 | 4462/50 |
| 别名 | N-[4-Bromo-2-(1H-tetrazol-5-yl-phen |
| 供应商 | Tocris |
| 生物活性 | Human ether-a-go-go (hERG) KV11.1 potassium channel activator. Activates the IKr current and displays antiarrhythmic activity. Exhibits potential dual mode of action at the hERG inhibitory site; may also act as a partial blocker of KV11.1 (hERG) channels. Displays selectivity over the key cardiac potassium ion channels, KV7.1 (KCNQ1), KV1.5, and KV4.3. Suitable for both in vitroandin vivouse. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 427.18 |
| 分子式 | C15H10BrF3N6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | George (2009) Restoring repolarization in LQT3. Heart Rhythm. 6 107. PMID: 19121809. Hansenet al (2007) Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 321 996. PMID: 17325228. Hansenet al (2006) Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 70 1319. PMID: 16825484. |