| 货号 | 2747/50 |
| 别名 | 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2 |
| 供应商 | Tocris |
| 生物活性 | GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 451.01 |
| 分子式 | C27H30N2O2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 13 mM in ethanol |
| CAS号 | 184845-43-0 |
| 参考文献 | Dalbyet al (1997) Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28 51. PMID: 9255599. Thomsenet al (1997) 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br.J.Pharmacol. 120 983. PMID: 9134205. |