| 货号 | 1347/50 |
| 别名 | N-[(1-Butyl-2-pyrrolidinyl)methyl]- |
| 供应商 | Tocris |
| 生物活性 | Highly potent, competitive, preferential dopamine D3 receptor antagonist. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively. Centrally active upon systemic administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 365.47 |
| 分子式 | C22H27N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. HCl |
| CAS号 | 149649-22-9 |
| 参考文献 | Richtandet al (2000) The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine. Brain Res. 867 239. PMID: 10837819. Audinotet al (1998) A comparative in vitroandin vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187. PMID: 9765337. Sautelet al (1995) Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. J.Pharmacol.Exp.Ther. 275 1239. PMID: 8531087. |