ML 347 (50 MG)
货号：
4945/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 4945/50 |
| 别名 | 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 352.39 |
| 分子式 | C22H16N4O |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Engerset al (2013) Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 23 3248. PMID: 23639540. |
