| 货号 | 4777/50 |
| 别名 | (2R)-N-[4-(4-Methoxyphenyl)-2-thiaz |
| 供应商 | Tocris |
| 生物活性 | Selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 471.59 |
| 分子式 | C23H25N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Yuet al (213) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc.Natl.Acad.Sci.U.S.A. 110 8732. PMID: 23650380. Mattmannet al (2012) Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator. Bioorg.Med.Chem.Lett. 22 5936. PMID: 22910039. |