| 货号 | 4196/50 |
| 别名 | B-[3-[[4-[[3-[(4-Fluorophenyl)methy |
| 供应商 | Tocris |
| 生物活性 | Selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 463.29 |
| 分子式 | C24H19BFNO5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Alberset al (2010) Discovery and optimization of boronic acid based inhibitors of autotaxin. J.Med.Chem. 53 4958. PMID: 20536182. Alberset al (2010) Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc.Natl.Acad.Sci.USA 107 7257. PMID: 20360563. |