GW 843682X (50 MG)
货号：
2977/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 2977/50 |
| 别名 | 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 477.46 |
| 分子式 | C22H18F3N3O4S |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 660868-91-7 |
| 参考文献 | Lansinget al(2007)In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol.Cancer Ther. 6 450. PMID: 17267659. |
