| 货号 | 1664/50 |
| 别名 | N-(2-Benzoylphenyl)-O-[2-(methyl-2- |
| 供应商 | Tocris |
| 生物活性 | Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 532.03 |
| 分子式 | C30H29N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol with gentle warming and to 100 mM in water |
| CAS号 | 196808-24-9 |
| 参考文献 | Nugentet al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 15 1729. PMID: 11579205. Wayet al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 276 25651. PMID: 11373275. Brownet al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415. PMID: 10389847. |