| 货号 | 4594/50 |
| 别名 | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetra |
| 供应商 | Tocris |
| 生物活性 | Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable. Ethyl ester derivative of GSK J1 (Cat. No. 4593). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 417.5 |
| 分子式 | C24H27N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Heinemannet al (2014) Inhibition of demethylases by GSK-J1/J4. Nature 514 E1. PMID: 25279926. Kruidenieret al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404. PMID: 22842901. |