| 货号 | 4593/50 |
| 别名 | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetra |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50 values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50>20μM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μM. Ethyl ester derivative also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 389.45 |
| 分子式 | C22H23N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Heinemannet al (2014) Inhibition of demethylases by GSK-J1/J4. Nature 514 E1. PMID: 25279926. Kruidenieret al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404. PMID: 22842901. |